Team Members

August Yue Huang, PhD

Principal Investigator

Harvard Catalyst Profile > 

Dr. Huang obtained his BS in Biological Science and PhD in Bioinformatics from Peking University, China. During his PhD studies, under the guidance of Dr. Liping Wei, he developed MosaicHunter, the first computational tool capable of systematically identifying somatic single-nucleotide variants from non-cancer whole-genome and exome sequencing data.

Dr. Huang then received his postdoctoral training with Drs. Christopher Walsh, Alice Lee, and Matthew Warman at Boston Children's Hospital and Harvard Medical School, where he pioneered in revealing the accumulation of somatic mutations in various tissue types and their contribution to many diseases including Alzheimer's disease, autism, and arteriovenous malformation.

In 2023, Dr. Huang opened his independent laboratory at the Division of Genetics and Genomics, Boston Children's Hospital, with a focus on utilizing computational genomic approaches to investigate the characteristics of somatic mutations in development and aging and their impact on human health. His research projects are being funded by NIH/NIA, NIH/NHLBI, Alzheimer's Association, and Boston Children’s Hospital​. 

Bowen Jin, PhD

Postdoctoral Fellow

Bowen joined the lab in 2023 after graduating from Case Western Reserve University with a PhD in Systems Biology and Bioinformatics. Her Ph.D. research is using single-cell RNA-seq to study transcriptomic burst kinetics and their association with aging. In addition, she has also studied the risk from rare coding variants for Alzheimer's disease in the context of protein structures. She is interested in advancing the computational tools in somatic mutation calling and investigating the effect of somatic mutation in neurodegenerative diseases.

Zheming An, PhD

Postdoctoral Fellow

Zheming joined the lab in 2023 after his postdoctoral training in Dr. Eduardo Sontag's lab at the College of Bioengineering at Northeastern University. He obtained his BS in Biological Sciences from Zhejiang University, and PhD in Computational and Integrative Biology from Dr. Benedetto Piccoli's lab at Rutgers University. His primary research involves the interdisciplinary study of mathematical modeling (dynamical systems and control theory), machine learning (physics-informed deep learning), and bioinformatics. He is interested in developing and applying new computational methods to study the role of somatic mutation in the human genome, focusing on cardiovascular biology. 

Irene Antony

Graduate Student

Irene is an MD-PhD candidate in the Harvard/MIT MD-PhD Program, with her MD through the HST track. She joined the lab in 2023 and is co-mentored by Dr. Christopher Walsh. She obtained her BA in Neuroscience at Washington University in St. Louis and is pursuing her PhD in the Program in Neuroscience at Harvard Medical School. For her PhD research, she is interested in studying early neurodevelopment and how genetic and epigenetic perturbations interact to cause different medical conditions. 

Yuchen Cheng

Research Assistant

Yuchen joined the lab in 2023 as a Master’s student and continued as a research assistant after completing her Master’s degree. She obtained her BS in Biomedical Informatics at Zhejiang University and the University of Edinburgh, and the MS in the same area from Harvard Medical School. She is interested in developing and applying computational tools for studying somatic mutation in neurodegenerative diseases.

Yong Shin

Research Assistant

Yong joined the lab in 2023. He obtained both his BA in Computer Science and MStat specializing in Bioinformatics, Statistical Genetics, and Biostatistics from Rice University. He is interested in understanding the mechanisms of different neurodegenerative diseases by identifying key mutations that are potentially causing them.

Close Collaborators

Christopher A. Walsh, MD, PhD

Chief and Professor

Boston Children's Hospital/Harvard Medical School

HHMI Investigator

Eunjung (Alice) Lee, PhD

Associate Professor

Boston Children's Hospital/Harvard Medical School

Michael B. Miller, MD, PhD

Assistant Professor

Brigham and Women's Hospital/Harvard Medical School

Sangita Choudhury, PhD

Assistant Professor

Boston Children's Hospital/Harvard Medical School

Sattar Khoshkhoo, MD

Incoming Assistant Professor

Brigham and Women's Hospital/Harvard Medical School